Triaryl methane compounds, pharmaceutical composition, and methods of inhibiting calcium-activated potassium transport from a cell, to reduce sickle cell dehydration and / or delay the occurrence of erythrocyte puffing or deformation, and treatment or prevention of disease, inhibiting cell proliferation in mammals, and treating or preventing a disorder.

摘要

"TRIARYL METHANIC COMPOUNDS, PHARMACEUTICAL COMPOSITION, AND METHODS OF POTASSIUM TRANSPORTATION ACTIVATED BY CALCIUM OF A CELL, TO REDUCE THE DEHYDRATION OF FALCIFORM ERYTOROUS ERITORACY ERYTOROUS ERITORACTION AND DETERMINING OCCURRENT OPERATION. , INHIBITION OF CELLULAR PROLIFERATION IN MAMMALS, AND TREATMENT OR PREVENTION OF A DISORDER ", and the present invention provides a class of chemical compounds useful as effective drugs in the treatment of sickle cell disease and diseases characterized by unwanted cell proliferation and not normal. The active compounds are compounds of substituted triaryl methane or analogues thereof, where one or more of the aryl groups is replaced by a heteroaryl, cycloaryl or heterocycloaryl group and / or where the tertiary carbon atom is replaced by a different atom, such as Si , Ge, N or P. The compounds inhibit cell proliferation in mammals, inhibit the Gardos erythrocyte channel, reduce sickle cell dehydration and / or delay the occurrence of erythrocyte pitting or deformation.