目的:探讨超声测定卵圆孔相关参数在胎儿左心发育不良产前诊断中的临床意义.方法:测量188例胎儿的卵圆孔相关参数,分析其随孕周变化的规律,比较其与左心发育不良的相关性.结果:188例胎儿中正常胎儿165例,左心发育不良胎儿23例(左心发育不良综合征12例、主动脉瓣狭窄8例、主动脉弓缩窄3例).正常胎儿的卵圆孔与主动脉内径相近,卵圆孔瓣开放径与主动脉内径的比值低于左心发育不良胎儿(P＜0.01),而卵圆孔瓣开放径与房间隔总长度的比值高于伴有左心发育不良的胎儿(P＜0.01).结论:超声心动图测定卵圆孔相关参数在胎儿左心发育不良的产前诊断中具有重要的辅助诊断价值.%Objective: To investigate the clinical significance of foramen ovale-related parameters examined by echocardiog-raphy in the prenatal diagnosis of hypoplastic left heart. Methods: One hundred and eighty-eight cases of fetal foramen ovale-related parameters were obtained, to analyze its change with the gestational age, and study the relationship between foramen ovale-related parameters and fetuses with hypoplastic left heart. Results: In the 188 cases, 165 cases were nomal and 23 cases were abmomal associated with hypoplastic left heart (12 cases were hypoplastic left heart syndrome, 8 cases were aortic valve aortic stenosis, 3 cases were coarctation of aorta). Normal fetal foramen ovale valve flap diameter was similar to the aortic diameter, and normal fetuses had a smaller ratio of foramen ovale valve flap diameter/aortic root size than fetuses with hypoplastic left heart(P<0.01), but had a larger ratio of foramen ovale valve flap diameter/atrial septum size(P<0.01). Conclusion: The foramen ovale-related parameters examined by echocardiography has important significance in prenatal diagnosis of hypoplastic left heart.
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