泮托拉唑序贯法治疗胃食管反流病的疗效观察

摘要

目的:观察泮托拉唑序贯法治疗胃食管反流病的临床疗效.方法:筛选出80例胃食管反流病患者,所有患者均有典型的反流症状及经胃镜检查明确诊断.采用双盲随机对照方法将其分为2组:序贯治疗组及单纯口服组（n=40）.序贯治疗组先予泮托拉唑粉针40mg静脉滴注,每日2次,2周后再予以泮托拉唑肠溶胶囊40mg口服,每日2次；单纯口服组予泮托拉唑肠溶胶囊40 mg口服,每日2次,2组疗程均为4周.在治疗前及治疗中,患者和医师共同记录烧心程度和频率,然后比较2组疗效.结果:两组均有较好的疗效,其中序贯治疗组总有效率优于单纯口服组(95.0％vs 77.5％,P＜0.05).结论:泮托拉唑序贯法治疗胃食管反流病具有较好的疗效.%Objective To observe the clinical efficacy of sequential therapy with pantoprazole in patients with gastro esophageal reflux disease (GERD). Methods A total of 80 patients with GERD were double-blindedly randomized into 2 groups; 40 patients received sequential therapy with pantoprazole 40 mg injection, twice daily for 2 weeks, and then pantoprazole 40 mg oral administration , twice daily for 2 weeks; the other 40 patients received pantoprazole 40 mg oral administration a-lone, twice daily for 4 weeks. Doctors and patients recorded the severity and frequency of heartburn before and during the treatment. The curative effects of the 2 groups were compared. Results The total effective rate in the sequential therapy group was higher than that of the oral administration group(95.0% vs 77.5% , P <0.05). Conclusion Pantoprazole sequential therapy is effective for GERD.