Objective To investigate the effect of combined artificial kidney, hemodia filtration and hemodialysis on the removal of β2-microglobulin (β2-MG) in uremic encephalopathy(UE). Method A retrospective randomized controlled study was used. Select 180 patients with UE.Randomly divided into three groups:hemodialysis (HD)group, hemodialysis filtration(HDF) group and the combination of artificial kidney (HD+HP) group, 60 cases/groups. hemodialysis group is 3/w blood dialysis. Hemodialysis filtration group is in the middle of 3/w dialysis in a HDF mode. The combined artificial kidney group is used in the middle of 3 /w dialysis in a HD+HP mode. The total course of treatment is 6w. Results 6 weeks after treatment.Three group of patients with serum creatinine, blood urea nitrogen, albumin, hemoglobin before and after treatment and compared differences had no statistical significance (P＞0.05). HD group : blood dialysis before,β2-MG there was no statistically significant difference compared with before treatment (P＞0.05); HDF group: bloodβ2-MG from (34.05±4.08)mg·L-1, fell to(22.49±3.51)mg·L-1.The difference was statistically significant compared with before treatment (P＜0.05);HD+HP group: β2-MG from (34.43±4.21)mg·L-1fell to(16.36±3.12)mg·L-1. The difference was statistically significant compared with before treatment (P＜0.05). 3 contrast HD+HP group blood β2-MG falling levels significantly lower than the HDF and HD group (P＜0.05). Conclusion Combination of artificial kidney can effectively remove UE patients bloodβ2-MG.%目的 探讨组合人工肾、血液透析滤过、血液透析对尿毒症脑病(UE)患者β2-微球蛋白(β2-MG)的清除效果.方法 选择180例UE患者,随机分为3组,普通血液透析(HD)组、血液滤过(HDF)组和组合人工肾组(HD+HP),每组60例.普通透析组行3次/w的血液透析治疗,血滤组在3次/w透析的中间一次用HDF模式,组合人工肾组在3次/w透析的中间一次用HD+HP模式,总疗程为6w.结果 治疗6w后,3组患者的血肌酐、尿素氮、白蛋白、血红蛋白等治疗前后比较,差异无统计学意义(均P＞0.05).HD组透析前血β2-MG与治疗前比较,差异无统计学意义(P＞0.05);HDF组血β2-MG从(34.05±4.08)mg·L-1降至(22.49±3.51)mg·L-1,与治疗前相比,差异有统计学意义(P＜0.05);HD+HP组β2-MG从(34.43±4.21)mg·L-1降至(16.36±3.12)mg·L-1,与治疗前相比,差异有统计学意义(P＜0.05).3组对比HD+HP组血β2-MG下降水平明显低于HDF组和HD组(P＜0.05).结论 组合人工肾可以更有效地清除UE患者血中的β2-MG.
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