肺结核患者外周血NK细胞数量和胞内杀伤分子的变化

摘要

目的:检测初治和复治结核病患者外周血NK细胞数量和胞内杀伤分子的变化.方法:取健康人(112名)和结核病患者145例(初治105例,复治40例)抗凝外周全血标本,加荧光标记抗CD3、CD56、CD8、颗粒酶和穿孔素抗体进行标记,进行流式细胞术检测.结果:初治肺结核患者外周血NK细胞的比例(16.95±8.27)%显著低于健康组(19.99±9.28)%(P0.05),而颗粒酶差异有统计学意义(P 0. 05 ) , but the difference of granzyme[ (79. 07 ±15.64)% vs (88.04 ±7.27)%] was significant( P <0. 01). Conclusions:The number of NK cells in peripheral whole blood of first-treated pulmonary TB patients NK was significantly decreased. However, the expressions of granulysin and perform in NK cells had no difference between pulmonary TB patients and healthy controls.