RASFs在类风湿性关节炎发病机制中的作用及其激活机制

摘要

Rheumatoid arthritis is a complex autoimmune disease,and its pathogenesis is very complex.The hyperplasia of the synovial tissue is one of the main pathological changes of the disease.A large number of scientific researches showed that activated synovial fibroblast had special characteristics of proliferation and played an important role in inflammarion,angiogenesis and tissue destruction in the process of the occurrence and development of rheumatoid arthritis (RA).The important role of synovial fibroblasts in the development of rheumatoid arthritis and the research progress of its activation mechanism were analyzed and discussed to provide references for the understanding of the pathogenesis mechanism of rheumatoid arthritis.%类风湿性关节炎(RA)是一种复杂的自身免疫性疾病,其发病机制十分复杂.滑膜组织的增生是该病的主要病理变化之一.大量科学研究结果表明,在类风湿性关节炎疾病的发生和发展过程中,激活的滑膜成纤维细胞(SFs)具有特殊的增殖特性,并在炎症反应、血管新生以及组织破坏等方面扮演重要角色.本文对滑膜成纤维细胞在类风湿性关节炎发生发展过程中的重要作用及其激活机制的研究进展进行分析和讨论,为认识类风湿性关节炎发病机制提供参考.