Derivatives of 5, 6, 7, 8 - tetrahidroimidazo 1,5a pyridine with aldosterone synthase Inhibitory activity, Pharmaceutical compositions containing them and their use in the preparation of drugs for the treatment of hiperaldosterismo and Cushing's Syndrome.

摘要

Pharmaceutical compositions containing them and their use in the manufacture of Medicines with Inhibitory activity of aldosterone synthase for the treatment and Prevention of Cushing's Syndrome, hypokalemia, hypertension, Primary and Secondary hiperaldosterismo and related diseases.Claim 1: a compound of General formula (1), in which X is n; c; Z is a link); R is H or alkyl); b is C1 C1 - 8 8 -, alkoxy, halogen or trifluoromethyl; r1 is alkyl alquenilo C1 - C2 - 8, 8, alquinilo C2 - 8 - alkyl, aryl or heterociclil C0 C0 - 4 - 4 unsaturated, whose Radicals are not s Ustituidos or are substituted by alkoxy C1 1 - 4 - 8 - alkoxy alkyl 8carbonilo C1, C1 - 8Alquilcarbonilo C0 - C1 - 8 8 alquilsulfonilo, aryl alkoxy C0 - 4 - aryl carbonyl, halogen, heterociclilo, cyano, trifluoromethyl, Oxo, trifluoromethoxy, or tri silyl c1-4 alkyl; R2 is H); or (b) is 8 C1 - C3 alkyl, cycloalkyl - 8, halogen, carboxy c1-4 alkyl, alcoxicarbonilo c1-4 alkyl, c1-4 alkyd Ilcarbonilo C0 - 4 alkyl, aryl or alkyl heterociclil C0 - C1 - 4 - 4 unsaturated.The Radicals are not replaced or substituted by alkoxy C1 1 - 4 - 8 - 8carbonilo C1 alkyl, alkoxy, alquilcarbonilo C0 - C1 - 8, 8, 8 alquilsulfonilo C1 -, aryl alkoxy C0 - 4 - aryl carbonyl, halogen, heterociclilo, cyano, trifluoromethyl, Oxo, trifluoromethoxy, or tri alkyl c1-4 silyl; n is u N Number 0, 1 or 2; and its SaltProdrug or compound in which one or more Atoms are replaced by their non Radioactive Stable Isotopes, in particular Salt useful from the point of view of Pharmaceuticals, where R2 is H, R1 is not naphthyl or carbazolyl.