a-硫辛酸、甲钴胺、前列地尔联合治疗糖尿病周围神经病变60例临床观察

摘要

Objective To study the clinical curative effect of α-lipoic acid (domestic) combined with the mMethylcobalamin and alprostadil combination therapy to 60 cases of diabetic peripheral neuropathy.Methods The 60 patients with diabetic peripheral neuropathy from March 2009 to March 2011 were divided into group A and group B,according to the random number table method,30 patients in each group.Group A used α-lipoic acid (domestic) combined with methylcobalamin and alprostadil three-drug combination treatment; group B used the methylcobalamin and alprostadil the two-drug combination treatment.After two weeks of treatment,the clinical efficacy of treatment as well as nerve conduction velocity in patients of the two groups were compared.Results Total effective rate of group A was 86.7％,B group was 66.7％,the clinical effect of the group A was significantly better than that of the group B (P＜0.05); nerve conduction velocity after treatment also showed significant improvement,but the clinical effects of group A was more obvious than group B (P＜0.05).Conclusions The effect of α-lipoic acid (domestic) combined with the methylcobalamin and alprostadil for diabetic peripheral neuropathy treatment is significant,the nerve conduction velocity of patients is significantly increased,worthy of clinical application.%目的 研究a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗糖尿病周围神经病变60例临床疗效.方法 选择2012年3月至2012年9月我院收治的60例糖尿病周围神经病变患者,按照随机数表法分为A组和B组两组.每组各30例.A组采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)三药联合用药进行治疗；B组采用甲钴胺(弥可宝)、前列地尔(凯时)两药联合进行治疗.治疗2周后,对两组患者的治疗临床疗效以及治疗后两组患者的神经传导速度进行比较分析.结果 A组治疗的总有效率为86.7％,B组治疗的总有效率为66.7％,A组治疗的临床效果明显优于B组(P＜0.05);治疗后,两组患者的神经传导速度均出现明显改善,但是采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗的A组,较采用甲钴胺(弥可宝)、前列地尔(凯时)联合治疗的B组改善效果更明显(P＜0.05).结论 采用a-硫辛酸(国产)、甲钴胺(弥可宝)、前列地尔(凯时)联合治疗糖尿病周围神经病变临床效果显著,可明显增加患者神经传导速度,值得临床推广应用.