早期应用辛伐他汀对高血压伴COPD的影响

摘要

目的 研究早期应用辛伐他汀对高血压伴慢性阻塞性肺炎(COPD)的影响.方法 将本院收治82例高血压伴COPD早期患者选为研究对象,按照治疗方式不同,分为对照组与研究组,每组41例.对照组采取常规疗法,研究组于其基础上予以辛伐他汀,对比两组右心室Tei指数、肺功能指标、血清NO以及CRP.结果 治疗后研究组右心室Tei指数[(0.47±0.07)]、PAPm[(30.36±2.15) mmHg]、血清CRP[(13.15±7.06) mg/L]明显小于对照组[(0.53±0.13)、(33.78±1.06) mmHg、(19.23±7.47)mg/L],且FEV1[(68.31±15.28)％]、FVC[(2.29±0.81)L]、血清NO[(55.17±9.03) mg/L]明显高于对照组[(60.56±14.34)％、(1.82±0.79)L、(45.96±7.62)mg/L] (P＜0.05).结论 早期应用辛伐他汀可对高血压伴COPD产生确切疗效,显著改善患者心肺功能及血清NO、CRP水平,临床应用价值高.%Objective To study the effect of early application of simvastatin on hypertension with chronic obstructive pulmonary disease (COPD).Methods A total of 82 hypertensive patients with COPD in our hospital were selected as study subjects and divided into the control group and the study group according to different treatment methods,41 cases in each group.The control group were treated with routine therapy,and the study group were additionally treated with simvastatin.The right ventricular Tei index,pulmonary function indexes,serum NO and CRP were compared between the two groups.Results The right ventricular Tei index,PAPm,and serum CRP level in the study group [(0.47±0.07),(30.36±2.15)mmHg,(13.15±7.06) mg/L] were significantly lower than those in the control group [(0.53±0.13),(33.78±1.06)mmHg,(19.23±7.47)mg/L],while FEV1,FVC,and serum NO level [(68.31±15.28)％,(2.29±0.81)L,(55.17±9.03)mg/L] were significantly higher than those in the control group [(60.56±14.34)％,(1.82±0.79)L,(45.96±7.62)mg/L] (P＜0.05).Conclusion Early application of simvastatin has definite therapeutic effect on hypertension and COPD,which can significantly improve the cardiopulmonary function,serum NO and CRP levels in patients.