双酚A引起胰岛素抵抗的机制

摘要

双酚A(bisphenol A,BPA),是一种类似雌激素活性作用的环境内分泌干扰物,也是世界上使用最广泛的工业化合物之一.研究证实长期暴露于BPA可以引起肥胖、性早熟、胰岛素抵抗(insulin resistance,IR)等.IR指胰岛素靶组织对胰岛素的敏感性降低,导致糖耐量异常和糖尿病的发生.大量的实验及临床研究发现BPA可以通过影响胰岛β细胞功能、葡萄糖转运及脂联素分泌引起IR.该文旨在对BPA引起IR的机制进行综述.%Bisphenol A(BPA) is one of the environmental endocrine disruptors with estrogenic properties,and it is also one of the most widespread compounds in the manufacture of polycarbonate plastics.Many studies confirmed that BPA exposure for long-term could lead to obesity,precocious puberty,insulin resistance (IR) et al.IR was defined as the decrease sensitivity in insulin action on the target tissues,which would result in impaired glucose tolerance and diabetes.A number of experiments and clinical investigations found that BPA could induce IR by affecting the function of islet beta cell,glucose transporter and adiponectin secretion.This review aims to summarize the mechanism of IR induced by BPA.