缺血修饰性清蛋白的临床应用研究

摘要

Objective To explore the ischemic modified albumin(IMA)in patients with acute coronary syndrome(ACS)early diagnaontic value.Methods In 89 cases of patients with ACS,present the onset of chest pain,2 h、6 h、12 h and 24 h blood test,IMA,cTnI and CK-MB.41 cases of acute myocardial infarction(AMI),angina pectoris 48 cases.IMA analysis for the diagnostic value of Acs.Results Patients with ACS、IMA level in onset of chest pain,2 h significantly higher peak,reched peak at 4 hours,returned tonormal at 6 hours.Instead CK-MB、cTnI 4 h began in the onset of chest pain increased significantly increased after 6 h,gradually increasing,myocandial infarction,IMA levels with angina in the most obvious(P＜0.05).Conclusion Early diagnosis of ACS IMA is sensitive indicators,the biochemical markers diagnosis of myocordial ischemia.%目的 探讨缺血修饰性清蛋白(IMA)在急性冠状动脉综合征(ACS)早期诊断价值.方法 将89例ACS患者分别于胸痛发作2、4、6、12 h及24 h采血检测IMA、肌钙蛋白I(cTnI)和肌酸激酶MB同功酶(CK-MB).其中急性心肌梗死41例,心绞痛48例.分析IMA对ACS的诊断价值.结果 ACS患者IMA水平于胸痛发作2 h明显增高,4 h达到高峰,6 h后降至正常.而cTnI,CKMB在胸痛发作4 h开始增高,6 h明显增高,以后逐步递增至24 h.在心绞痛、心肌梗死中,IMA水平升高以心绞痛最明显(P＜0.05).结论 IMA是诊断ACS早期敏感指标,是诊断心肌缺血的生化标志物.