method for increasing intracellular copper level in an ischemic tissue, method for specifically delivering copper to cells of an ischemic tissue, method for inducing at least two tissue repair events in an ischemic tissue, method for inducing stem cell migration for an ischemic tissue, method for promoting copper-dependent hif-1 transcriptional activities in an ischemic tissue, pharmaceutical composition, use of a composition, composition and kit

摘要

These are repair and regeneration methods of ischemic tissue by promoting tissue redistribution and reuse of copper by administering a composition comprising a copper chelating tetramine such as trientine. methods and compositions for increasing intracellular copper level and / or inducing repair of an ischemic tissue in an individual. Increased copper level in an ischemic tissue may promote copper-dependent hif-1 transcriptional activities and tissue repair.