Compound, pharmaceutical composition, methods to treat or prevent cancer in a mammal, a disease in which angiogenesis is involved, retinal vascularization, diabetic retinipathy, age-related macular degeneration, inflammatory disease, a disease or condition dependent on tyrosine kinase and, bone-related pathologies, process for making a pharmaceutical composition, and method for reducing or preventing tissue damage following an ischemic event

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING OR PREVENTING CANCER IN A MAMMALIAN, A DISEASE IN WHICH ANGIOGENESIS IS IMPLIED, RETINAL VASCULARIZATION, DIABETIC RETINIPATHY, AGAINSTEACTION OF AGAINSTEACTION. OF TYROSINE KINASE AND, BONE-RELATED PATHOLOGIES, PROCESS TO MANUFACTURE A PHARMACEUTICAL COMPOSITION, AND, METHOD TO REDUCE OR PREVENT TISSUE DAMAGE THAT FOLLOWS AN ISCHEMIC EVENT. " The present invention relates to compounds that inhibit, regulate and / or modulate tyrosine kinase signal transduction, compositions containing these compounds and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor development, arteriosclerosis, age-related macular degeneration, diabetic retinopathy, inflammatory disease and others in mammals.