2型糖尿病肾病患者血清脂联素、内脂素、白细胞介素-18检测的临床意义

摘要

目的 探讨对2型糖尿病(T2DM)肾病患者检测血清脂联素、内脂素、白细胞介素-18(IL-18)3个指标的临床意义.方法 选择该院确诊的96例T2DM患者作为观察组进行研究,且根据患者尿清蛋白排泄率分为3组,分别是正常尿蛋白组、微量尿蛋白组、大量尿蛋白组.另随机选同期来该院体检的健康者32例作为对照组.采用ELISA法检测各组血清中脂联素、内脂素、IL-18水平,比较各组以上3个指标的水平变化.结果 观察组3组的IL-18、内脂素的水平均明显高于对照组(P＜0.05),正常尿蛋白组血清脂联素低于对照组(P＜0.05)；微量尿蛋白组和大量尿蛋白组的脂联素明显高于对照组(P＜0.05)；内脂素、IL-18、脂联素与病程、HbA1c、FPG、TG、TC、LDL、BUN、Scr、UAER呈正相关,与HDL呈负相关,且内脂素、IL-18、脂联素三者互呈正相关性.结论 血清脂联素、内脂素、白细胞介素-18的水平与2型糖尿病肾病的发生、发展密切相关,在临床检测中具有重要意义.%Objective To explore the significance of serum adiponectin,visfatin and interleukin-18 in patients with type 2 diabetic nephropathy.Methods 96 patients with type 2 diabetes mellitus were divided into normal albuminuria group,micro albuminuria group and macro albuminuria group according to the urinary albumin excretion rate(UAER),and 35 healthy cases were the control group.The serum levels of adiponectin,visfatin and IL-18 were measured by ELISA.Results The serum levels of adiponectin,visfatin and interleukin 18 in observation group were significantly higher than control group(P＜0.05).The level of adiponectin in normal albuminuria group was lower than the control group(P＜0.05),while it was significantly higher in the micro albuminuria group and macro albuminuria group than that in the control group(P＜0.05).Visfatin,IL-18 and adiponectin had a positive correlation with duration,HbA1c FPG,TG,TC,LDL,BUN,Scr and UAER,but had a negative correlation with HDL.There was a positive correlation among the three proteins.Conclusion The serum levels of adiponectin,visfatin,interleukin-18 in type 2 diabetic nephropathy were closely related to the occurrence and development,and were important in clinical diagnosis and treatment.