Detection of Serum Vascular Endothelial Growth Factor (VEGF) and Endothelin, in Type 2 Diabetic Nephropathy Patients and Its Clinical Significance

摘要

To investigate the relationship between the content of serum factor (VEGF) and endothelin with complication of type 2 diabetic mellitus. One-hundred patients of diabetic nephropathy, fifty diabetic mellitus without renal dysfunction and fifty healthy volunteers were enrolled. The serum levels of vascular endothelial growth factor (VEGF) were measured with enzyme end method and endothelin were measured with radioimmunoassay method. The results show that vascular endothelial growth factor (VEGF) and endothelin were significantly higher in diabetic nephropathy patients than the other patients. Vascular endothelial growth factor (VEGF) and endothelin can be a reliable indicator for early impairment of renal function, and will be helpful for diagnosis of type 2 diabetic nephropathies.