Elevated expression levels of serum insulin‐like growth factor‐1, tumor necrosis factor‐α and vascular endothelial growth factor 165 might exacerbate type 2 diabetic nephropathy

摘要

Abstract Aims/IntroductionThe present study aimed to determine the associations between expressions of insulin-like growth factor-1 (IGF-1), tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor 165 (VEGF₁₆₅) in serum, and occurrence and development of type 2 diabetic nephropathy (DN). Materials and MethodsA total of 108 patients diagnosed as DN were randomly selected, including 50 patients in the microalbuminuria group, 44 patients in the macroalbuminuria group and 14 patients in the renal insufficiency group. Meanwhile, 97 healthy people were collected as a normal control group. Urinary albumin (UALB) and urine creatinine (Cr) of all participants were measured for 24 h, with their ratio (UALB/Cr) being calculated. Enzyme-linked immunosorbent assay was used to detect the serum concentrations of IGF-1, TNF-α and VEGF₁₆₅. ResultsThe expressions of serum IGF-1, TNF-α and VEGF₁₆₅ in the type 2 DN patients were significantly higher than those in the control group (all P 165 in the type 2 DN patients were positively correlated with UALB/Cr (all P 165 increased, and type 2 DN severity had positive correlations with serum IGF-1, TNF-α and VEGF₁₆₅ concentrations (all P 165, and TNF-α and VEGF₁₆₅ (all P 165 were associated with the progression of DN (both P ConclusionsElevated expression levels of serum IGF-1, TNF-α and VEGF₁₆₅ might exacerbate type 2 DN.