目的 探讨糖尿病肾病(DN)患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)水平的变化.方法 将63例2型糖尿病(T2DM)患者根据是否并发肾脏损害分为T2DM组35例和DN组28例,另选同期体检健康者30人为正常对照组,检测3组血清CRP、TNF-α和VEGF水平,并进行比较.结果 T2DM组和DN组患者血清CRP、TNF-α和VEGF水平显著高于正常对照组,差异有统计学意义(P ＜0.05)；DN组患者血清CRP、TNF-α和VEGF水平显著高于T2DM组,差异有统计学意义(P＜0.05).结论 CRP、TNF-α和VEGF可能与DN的发生和发展有关.%Objective To explore the change of the levels of serum C reactive protein(CRP) ,tumor necrosis factor-α (TNF-α)and vascular endothelial growth factor (VEGF) in patients with diabetic nephropathy ( DN). Methods Sixty-three patients with type 2 diabetes mellitus(T2DM) were divided into T2DM group(n=35) and DN group(n= 28) according to whether complicated with renal damage, and thirty healthy people were chose as normal control group. The levels of serum CRP,TNF-α and VEGF were detected and compared in three groups. Results The levels of serum CRP,TNF-α and VEGF in T2DM group and DN group were significantly higher than those in normal control group,the differences were statistically significant(P <0. 05). The levels of serum CRP,TNF-α and VEGF in DN group were significantly higher than those in T2DM group, the differences were statistically significant ( P < 0. 05 ) . Conclusion CRP, TNF-α and VEGF may be related to the occurrence and development of DN.
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