2型糖尿病肾病患者血清白细胞介素-9、白细胞介素-17和转化生长因子-1的水平及临床意义

摘要

Objective:To investigate the levels and clinical significance of interleukin 9(IL-9),IL-17 and transforming growth factor beta1 (TGF-1 )in patients with diabetic nephropathy (DN).Methods:According to the ratio of micro-albuminuria to creatinine, 62 patients with type 2 diabetes mellitus (T2DM)were divided into the T2DM group (32cases)and DN group (30 cases),and the 30 healthy persons were set as the control group(NC group).The serum biochemistry markers and urine albumin levels in three groups were detected using routine biobemical methods.The levels of IL-9,IL-17 and TGF-1 in three groups were detected by the ELISA,the difference of which was analyzed.Results:The levels of IL-9,IL-17 and TGF-1 in DN group were significantly higher than those in T2DM and NC group(P <0.01 ).Conclusion:The levels of IL-9,IL-17 and TGF-1 in serum of type 2 diabetes patients with nephropa-thy increased,which may play an important role in the occurrence and development of diabetic nephropathy.%目的：探讨2型糖尿病（type 2 diabetes mellitus，T2DM）肾病患者白细胞介素-9（IL-9）、IL-17和转化生长因子-1（TGF-1）水平的变化及其临床意义。方法：根据尿微量白蛋白与肌酐比值，将62例 T2DM 患者分为糖尿病非肾病组（T2DM组）32例和糖尿病肾病组（DN 组）30例，另选健康对照组（NC 组）30名。常规方法检测血清生化指标和尿蛋白含量，酶联免疫吸附法测定 IL-9、IL-17及 TGF-1水平。分析3组血清 IL-9、IL-17和 TGF-1水平差异。结果：DN 组 IL-9、IL-17和 TGF-1水平显著高于 T2DM组和 NC 组（P ＜0．01）。结论：T2DM肾病中患者血清 IL-9、IL-17和 TGF-1水平升高，可能在 T2DM肾病的发生及发展过程中起重要作用。