涂阳肺结核患者 TB-DNA 定量、γ干扰素释放试验、结核抗体检测的价值

摘要

Objective To investigate the value of quantitative TB‐DNA test ,interferon gamma release test and the detection of tuberculosis antibodies for the diagnosis of active pulmonary tuberculosis .Methods 51 patients were diagnosed as tuberculosis from 2013 July to 2014 June in the hospital ,whose sputum smear microscopy for acid fast bacilli were positive .Then TB‐DNA quantitative test ,interferon gamma release test (T‐SPOT .TB)and tuberculosis antibody detection were performed for those pa‐tients .All the result were retrospectively analysed .Results The positive rate of T‐SPOT .TB was 90 .1% ,the positive rate of quan‐titative TB‐DNA test was 74 .5% and the positive rate of tuberculosis antibody detection was 37 .3% .Conclusion Because the re‐sult of T‐SPOT .TB is not affected by the process of specimen collection ,it is the most sensitive test of the three tests at present , and has higher value in the auxiliary diagnosis of active pulmonary tuberculosis than the other two .%目的：探讨肺结核（TB）‐DNA定量、γ干扰素释放试验（T‐SPOT．TB）、结核抗体检测对活动性肺结核辅助诊断的价值。方法回顾性分析2013年7月至2014年6月入院确诊为肺结核且抗酸杆菌痰涂片阳性51例患者的TB‐DNA定量、T‐SPOT．TB、结核抗体检测指标。结果T‐SPOT．TB检测阳性率为90．2％，灵敏度最高；其次为TB‐DNA定量，阳性率为74．5％；结核抗体检测阳性率仅为37．3％，灵敏度最低。结论T‐SPOT．TB检测不受标本采集的影响，灵敏度高，对活动性肺结核的辅助诊断具有较高价值。