Objective:To evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary stenosis in young patients with coronary atherosclerotic disease (CAD).Methods:One hundred and fifteen patients under 45 years old who had undergone coronary angiography were retrospectively selected,who were divided into CAD group (n =74) and non-CAD group (n =43) according to the result of angiography.The patients in CAD group were divided into two groups according to their Gensini score:high score group (≥30 points,n =32) and low score group (＜30 points,n =40).NLRs were calculated in all patients.The differences of CAD risk factors between the CAD group and non-CAD group were compared.Multivariate logistic regression was used to analyze the relevance between severity of coronary artery lesions and NLR.Results:Compared with non-CAD group,the sex ratio,incidence of hypertension and smoking,γ-glutamyltranspeptidase (GGT),triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),uric acid (UA),high sensitive C reactive protein (hs-CRP) level,white blood cell count (WBC) and NLR were all significantly increased in CAD group.Multivariate logistic regression analysis showed that adjusting for smoking,hs-CRP,GGT and other factors,NLR remained as an independent risk factor forthe severity of coronary stenosis in young CAD patients (OR=2.501,95％ CI =1.439～4.364,P =0.001).Conclusion:NLR can be an independent predictor for the severity of coronary stenosis in young CAD patients.%目的:探讨中性粒细胞/淋巴细胞计数比值(NLR)与青年冠状动脉(冠脉)硬化性心脏病(CAD)患者冠脉狭窄程度的关系. 方法:回顾性选取45岁以下行冠脉造影者115例,根据造影结果分为CAD组(n=74)和非CAD组(n=43).按冠脉病变程度Gensini积分将青年CAD患者分为高积分组(≥30分,n=32)和低积分组(＜30分,n=40).比较CAD组与非CAD组的危险因素差异,并采用多因素logistic回归分析NLR与冠脉病变程度的相关性. 结果:与非CAD组相比,CAD组男性、吸烟及高血压占比、γ-谷腺肽转氨酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)及NLR均明显升高,差异具有统计学意义(P均＜0.05).多因素logistic回归分析显示,在校正吸烟、hs-CRP、GGT等因素后,NLR仍是青年CAD患者冠脉狭窄程度的独立危险因素(OR=2.501,95％CI:1.439～4.364). 结论:NLR可作为青年CAD患者冠脉狭窄程度的独立危险因素.
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