舒芬太尼复合布托啡诺用于老年妇科术后镇痛的临床观察

摘要

Objective To evaluate the efficacy and safety of butorphanol and sufentanil in patient-controlled intravenous analgesia after senile gynecologic operation. Methods Sixty ASA Ⅰ ～ Ⅱ patients undergoing elective extended hysterectomy were randomized into 2 groups who received PCIA with 0.175 μg/kg sufentanil (group S) and 0.1 μg/kg sufentanil with 0.01 mg/kg butorphanol ( group BS),30 patients in each group. At 4、8、12、20、24、48 h after operation visual analogue scale (VAS) of pain score were recorded. The Ramsay sedation scoring assessment was used to evaluate the sedation level. The adverse reactions and the overall patient satisfaction were statistically analysed. Resuits n the two groups of patients at different time points,VAS scores had no statistically significant difference (P＞0.05) ,but The Ramsay scores of group BS were significantly higher than those of group S (P＜0.05). the overall patient satisfaction of group BS were significantly higher than that of group S(P ＜ 0. 05), The prevalence of side effects in group BS was significantly lower than that in groups S. Conclusion Sufentanil combined butorphanol in PCIA exhibits satisfactory effect and minor side effects,which is a safe and effective method of postoperative analgesia.%目的 探讨舒芬太尼复合布托啡诺用于老年妇科术后患者自控静脉镇痛(PCIA)的临床效果及其安全性.方法 60例ASA Ⅰ～Ⅱ级拟择期行子宫全切除术的患者,随机分为两组,每组30例.S组给予舒芬太尼0.175μg/kg以及BS组给予舒芬太尼0.1 μg/kg和布托啡诺0.01 mg/kg行术后镇痛治疗,分别记录术后4h、8 h、12 h、20 h、24h、48 hVAS疼痛评分及Ramsay镇静、恶心、呕吐评分,患者总体满意度等.结果 两组患者术后各时间点VAS评分比较,差异无统计学意义(P＞0.05),BS组Ramsay镇静评分明显高于S组(P＜0.05),BS组镇痛总体满意度明显高于S组(P＜0.05),BS组不良反应的发生率明显低于S组(P＜0.05).结论 舒芬太尼复合布托啡诺用于老年妇科手术后镇痛效果更确切,不良反应发生率更低.