Objective To study the relationship between the expression of matrix metalloproteinases (MMPs) and clinical prognosis in patients with acute ischemic stroke in the early stage, and to provide basis for clinical diagnosis and treatment. Methods Ninety patients of acute ischemic stroke from December 2014 to December 2015 in our hospi-tal were selected and followed up for 90 days. The prognosis of patients was evaluated by modified Ranking scale (mRS): patients with 0-1 of mRS score were divided into good prognosis group, and patients with 2-6 of mRS score were included in the poor prognosis group. The levels of matrix metalloproteinases-2 (MMP-2), matrix metalloproteinas-es-9 (MMP-9) and matrix metalloproteinases-13 (MMP-13) were compared between the two groups. The correlations be-tween MMP-2, MMP-9, MMP-13 and mRS score were analyzed. Results The levels of MMP-2 and MMP-13 in the two groups were (241.29±10.42)μg/L, (79.29±3.45)μg/L, (243.45±9.58)μg/L, (83.42±5.08)μg/L, showing no statistical-ly significant difference (P>0.05). The level of MMP-9 in poor prognosis group was significantly higher than that in good prognosis group, (153.42±20.98)μg/L vs (79.24±8.52)μg/L, and the difference was statistically significant (P<0.05). Pear-son correlation analysis showed that MMP-9 was positively correlated with mRS score (r=0.856, P=0.002), and that there was no correlation between MMP-2, MMP-13 and mRS score (r=0.483, 0.503, P=0.086, 0.082). Conclusion MMP-9 has predictive effect on the prognosis of patients with acute ischemic stroke, and the levels of MMP-2 and MMP-13 are not related to the prognosis of patients with acute ischemic stroke.%目的：探讨急性缺血性脑卒中患者超早期基质金属蛋白酶（MMPs）表达水平与临床预后的关系。方法选取2014年12月至2015年12月我院收治的急性缺血性脑卒中患者90例，随访患者90 d，应用改良Ranking量表(mRS)评价患者的预后，mRS评分0~1分纳入预后良好组(50例)，mRS评分2~6分纳入预后不良组(40例)，比较两组患者入院时基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶-13(MMP-13)水平，分析MMP-2、MMP-9及MMP-13与mRS评分的相关性。结果预后良好组和预后不良组患者的MMP-2和MMP-13水平分别为(241.29±10.42)µg/L、(79.29±3.45)µg/L和(243.45±9.58)µg/L、(83.42±5.08)µg/L，差异均无统计学意义(P>0.05)；预后不良组患者的MMP-9水平为(153.42±20.98)µg/L，明显高于预后良好组的(79.24±8.52)µg/L，差异具有统计学意义(P<0.05)；Pearson相关性分析显示：MMP-9与mRS评分呈正相关关系(r=0.856，P=0.002)，MMP-2、MMP-13与mRS评分无相关关系(r=0.483、0.503，P=0.086、0.082)。结论 MMP-9对急性缺血性脑卒中预后具有预测作用，MMP-2和MMP-13水平与急性缺血性脑卒中预后无关。
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