经颅直流电刺激对急性脑梗死患者血清Hcy及hs-CRP的影响

摘要

Objective To investigate effect of the transcranial direct current stimulation (tDCS) on the level of the serum homocysteine (Hcy) and high-sensitive C reactive protein (hc-CRP) in patients with acute cerebral infarction. Methods A total of 106 patients with acute cerebral infarction in Department of Rehabilitation in the First People's Hospi-tal of Foshan from February 2013 to November 2014 were selected. The patients were divided into the control group (n=53) and the observation group (n=53) according to the random number table. The patients in control group only received routine drug therapy, and the rehabilitation therapy was carried out by using facilitation technique. The observation group was treat-ed with transcranial direct current stimulation on the basis of the control group. The serum levels of Hcy and hs-CRP were compared between the two groups before and after treatment. FMA (motor function score) and Barthel index (BI) were used to evaluate the therapeutic effect. Results After treatment, the levels of Hcy and hs-CRP in the observation group were significantly lower than those in control group [(11.41±1.15)μmol/L vs (16.65±4.33)μmol/L, (9.32±1.87) mg/L vs (12.36±1.85) mg/L, P<0.05]. After treatment, FMA, BI scores in the observation group were significantly higher than those in control group [(66.7±24.6) vs (53.8±22.6), (70.5±12.8) vs (47.2±12.3), P<0.05]. Conclusion Transcranial direct cur-rent stimulation in the treatment of acute cerebral infarction can effectively reduce serum Hcy and hs-CRP levels, pro-mote the recovery of limb function, and improve the therapeutic effect.%目的：探讨经颅直流电刺激(tDCS)对急性脑梗死患者血清同型半胱氨酸(Hcy)和高敏C反应蛋白(hc-CRP)水平的影响。方法按照随机、对照方法将佛山市第一人民医院康复科在2013年2月至2014年11月收治的106例急性脑梗死住院患者分为两组(n=53)，对照组患者实施常规药物治疗，并应用促通技术进行康复治疗，观察组在此基础上加用经颅直流电刺激疗法，比较两组患者治疗前后的血清Hcy、hs-CRP水平变化，并应用FMA (运动功能评分)和Barthel指数(BI)评估治疗效果。结果观察组患者治疗后的Hcy、hs-CRP水平分别为(11.41±1.15)μmol/L、(9.32±1.87) mg/L，均明显低于对照组的(16.65±4.33)μmol/L、(12.36±1.85) mg/L，组间比较差异均有统计学意义(P<0.05)；观察组患者治疗后的FMA、BI评分分别为(66.7±24.6)分、(70.5±12.8)分，均明显高于对照组的(53.8±22.6)分、(47.2±12.3)分，组间比较差异均有统计学意义(P<0.05)。结论经颅直流电刺激治疗急性脑梗死能有效降低血清Hcy、hs-CRP水平，促进肢体运动功能恢复，提高治疗效果。