深圳市石岩街道学龄期儿童幽门螺旋杆菌感染状况及对患儿营养状态的影响

摘要

目的 调查深圳市石岩街道学龄期儿童幽门螺旋杆菌(Hp)感染状况,并分析其对患儿营养状况的影响.方法 收集2016年07月至2017年3月深圳市石岩街道的300例学龄期儿童为研究对象,均施行13C尿素呼气试验(13C-UBT),并对纳入研究的儿童监护人进行问卷调查,观察纳入研究儿童Hp感染状况,依据有无感染Hp分为感染组和未感染组,对儿童感染Hp的危险因素进行单因素及多因素Logistic分析,并比较感染组及未感染组的血清铁蛋白、身高、体质量等营养状态.结果 300例受试儿童总Hp感染率为26.67％,有胃肠道症状儿童Hp感染率为45.00％,明显高于无胃肠道症状儿童的17.50％,差异有统计学意义(P<0.05);单因素及Logistic分析结果显示,无专用餐具、监护人学历低、啃玩具或手指、家庭月收入低及有家族胃肠道疾病史均是本组学龄期儿童感染Hp的独立危险因素(P<0.05);感染组和未感染组儿童的血清铁蛋白[(19.32±1.90)μg/L vs(30.08±2.19)μg/L]、身高[(83.49±2.28)cm vs(120.50±4.89)cm]、体质量[(12.59±1.28)kg vs(15.49±3.39)kg]比较,感染组均低于未感染组,差异均有统计学意义(P<0.05).结论 深圳市石岩街道6～12岁学龄期儿童Hp感染率仍处于较高水平,Hp感染严重影响儿童期营养.无专用餐具、监护人学历低、啃玩具或手指、家庭月收入低及有家族胃肠道疾病史均是导致儿童期Hp感染的独立危险因素.%Objective To investigate the status of Helicobacter pylori (Hp) infection in school-age children at Shiyan Street in Shenzhen, and analyze its effect on the nutritional status of children. Methods A total of 300 school-age children at Shiyan Street in Shenzhen were selected as the research subjects from July 2016 to March 2017. All children underwent 13C-urea breath test (13C-UBT), and a questionnaire survey was conducted on the guardians of se-lected children. The status of Hp infection in selected children was observed, and according to whether there was Hp in-fection, they were divided into the infected group and the uninfected group. Risk factors of Hp infection in children were analyzed by univariate and multivariate logistic analysis. The serum ferritin, height and weight were compared between the two groups. Results The Hp infection rate in 300 children was 26.67％, and the Hp infection rate in children with gastrointestinal symptoms was 45.00％, which was significantly higher than 17.50％in children without gastrointestinal symptoms (P<0.05). Univariate and logistic analysis showed that no special tableware, low education level of the guardians, biting toys or fin-gers, low family income and family history of gastrointestinal diseases were the independent risk factors of Hp infection in children in the study (P<0.05). There were significant differences between the infected group and the uninfected group in serum ferritin (19.32±1.90)μg/L vs (30.08±2.19)μg/L, height (83.49±2.28) cm vs (120.50±4.89) cm and weight (12.59±1.28) kg vs (15.49± 3.39) kg (P<0.05). Conclusion The Hp infection rate in school-age children at Shiyan Street in Shenzhen is high. Hp infection has significant effect on the nutritional status of children. No special tableware, low education level of the guardians, biting toys or fingers, low family income and family history of gastrointestinal diseases are the independent risk factors of Hp infection in children.