婴幼儿非感染性腹泻乳糖不耐受情况分析

摘要

Objective To investigate the development of lactose intolerance in infants with non-infectious diar-rhea. Methods From March 2015 to December 2016, 89 infants of non-infectious diarrhea were selected as study group,and 134 healthy infants were enrolled as control group.The galactose oxidase method was used to detect urine ga-lactose,and the lactose intolerance in two groups was statistically analyzed.Results The positive rate of lactose intoler-ance was 68.50%(61/89)in the study group versus 19.40%(26/134)in the control group(P<0.01).The positive rate of lactose intolerance was significantly higher in the study group than the control group in a particular age period(P<0.05):80.65% vs 24.49% for 0~6 months old infants,76.92% vs 19.05% for 6 months-1 year old infants,55.00% vs 16.67% for 1-2 years old infants,41.67% vs 10.53% for 2-3 years old infants.Further analysis showed that the positive rate of lac-tose intolerance decreased with age.Conclusion The incidence of lactose intolerance in infants with non-infectious di-arrhea is high,and urinary galactose detection should be carried out in order to make timely and effective treatment.%目的 探讨婴幼儿非感染性腹泻时乳糖不耐受的发生情况.方法 选取2015年3月至2016年12月南京市鼓楼区妇幼保健所儿科门诊就诊的89例非感染性腹泻婴幼儿为观察组,以同期在本所进行健康体检的134例健康婴幼儿为对照组.采用半乳糖氧化酶法检测全部婴幼儿的尿半乳糖,对两组婴幼儿乳糖不耐受情况进行统计学分析.结果 观察组婴幼儿乳糖不耐受阳性率为68.50%(61/89),明显高于对照组的19.40%(26/134),差异有统计学意义(P<0.05).随着年龄的增长,乳糖不耐受的阳性率呈下降趋势.同一年龄段的婴幼儿乳糖不耐受阳性率比较,观察组明显高于对照组(年龄<6个月:80.65% vs 24.49%;6个月≤年龄<1岁:76.92% vs 19.05%;1岁≤年龄<2岁:55.00% vs 16.67%;2岁≤年龄<3岁:41.67% vs 10.53%),差异均有统计学意义(P<0.05).结论 婴幼儿非感染性腹泻时乳糖不耐受的发生率高,对诊断为非感染性腹泻的婴幼儿应进行尿半乳糖检测,以便及时有效地进行干预治疗.