大剂量阿托伐他汀短期干预心力衰竭患者对于血浆APN、hs-CRP水平的变化影响

摘要

Objective To investigate the plasma the APN and hs-CRP changes of high-dose atorvastatin short-term intervention in patients with congestive heart failure for observating the efficacy of the mechanism. Methods Selected 60 cases of heart failure patients as the observation group and 60 cases of healthy people as control group, the observation group were given high-dose atorvastatin short-term intervention. Detected all cases’ left ventricular ejection fraction (LVEF) and plasma APN and hs-CRP changes. Results After treatment, the hsCRP and APN levels were decreased significantly in the observation group (P<0.05), the LVEF level was significantly increased (P<0.05) that were basically reached the level of the control group (P>0.05). Linear analysis showed that the APN and hs-CRP were negatively correlated. To the LVEF. Conclusion High-dose atorvastatin short-term intervention in patients with congestive heart failure can significantly reduce hsCRP and APN levels that participate in the ventricular remodeling of heart failure patients, there will be conducive to disease control should be widely applied.%　　目的探讨大剂量阿托伐他汀短期干预心力衰竭患者对于血浆APN、hs-CRP水平的变化,分析疗效发生机制.方法选择心力衰竭患者60例作为观察组和60例健康体检人作为对照组,观察组患者采用大剂量阿托伐他汀短期干预治疗.检测两组的左室射血分数(LVEF)和血浆APN和hs-CRP的变化.结果经过治疗后,观察组hsCRP与APN值有明显下降(P<0.05),LVEF值有明显升高(P<0.05),基本达到了对照组水平(P>0.05).经过直线分析,APN和与hs-CRPLVEF呈负相关.结论大剂量阿托伐他汀短期干预心力衰竭能明显降低hsCRP与APN水平,从而参与到心力衰竭患者的心室重构,将有利于病情的控制,值得推广应用.