QuEChERS－HPLC－MS／MS 在动物源食品兽药多残留检测中的研究进展

摘要

In recent years, the food safety problem of animal-origin foods increasingly becomes one of the focus of the government and the society.The drug residue of animal-origin foods seriously has impaired the environment and human health, and the existing methods of veterinary drug residues have the disadvantages of pretreatment complexity, time-consuming and detecting singleness, low sensitivity.QuEChERS is quick, easy, cheap, effective, rugged and safe method for pesticide multi-residue analysis based on dispersive solid phase extraction, combined with high sensitivity and selectivity of high performance liquid chromatography mass spectrometry ( HPLC/MS/MS ) , has been widely applied in the veterinary drug residues in animal food detection.The principle, characteristics, the basic step of QuEChERS method, and the application progress of QuEChERS-HPLC-MS/MS in the field of veterinary drug residue analysis were described.%近年来动物源食品安全问题日益成为社会和政府关注的焦点之一。动物源食品兽药残留严重危害环境和人体健康，同时现有的兽药多残留检测方法存在前处理复杂、耗时，检测种类单一，灵敏度较低等弊端。 QuEChERS是基于分散固相萃取（DSPE）建立起来的一种农药多残留快速（quick）、简单（easy）、便宜（cheap）、高效（effective）、耐用（rugged）和安全（safe）的分析方法，并结合高灵敏度和高选择性的超高效液相色谱串联质谱（ HPLC－MS／MS），已经广泛应用于动物性食品中兽药残留检测。本文阐述了QuEChERS方法的原理、特点和基本步骤，以及我国近年来QuEChERS－HPLC－MS／MS在动物源性食品兽药多残留检测中的应用进展。