Objective To explore the association between preprocedural serum level of oxidized low-density lipoprotein( ox-LDL ) and in-stent restenosis( ISR ) in patients undergoing percutaneous coronary intervention( PCI ). Methods A search for the related Chinese or English studies( from January 1990 to March 2012 ) on the association between preprocedural serum ox-LDL level and ISR in PCI patients was conducted in databases including MEDLINE, CBM, VIP and CNKI. A Meta-analysis was performed. Results Seven cohort studies including 782 patients( 165 ISR and 617 no-ISR patients ) were included. The result of Meta-analysis showed that no significant association was found between high preprocedural serum ox-LDL level and ISR( P > 0. 05 ), significant heterogeneity existed among studies ( P <0. 001 ),patients' age was the major source of heterogeneity( P <0.05 ). Significant association of high preprocedural serum ox-LDL level with ISR was found in patients aged 60 years or older( P <0.05 ). Conclusion Association of higher preprocedural serum ox-LDL level with ISR can not be found in PCI patients except the ones aged 60 years or older.%目的 探讨术前血清氧化低密度脂蛋白(ox-LDL)水平与冠状动脉支架内再狭窄(ISR)相关性.方法 在MEDLINE、CBM、VIP、中国期刊全文数据库(CNKI)等检索1990年1月至2012年3月有关术前血清ox-LDL水平与ISR相关性的中、英文文献,采用Meta分析方法 进行分析.结果 纳入7篇文献共782例患者,其中ISR组165例,非ISR 617例.Meta分析结果 表明,术前血清ox-LDL水平高与ISR无相关性(P＞0.05),单个研究之间存在显著异质性(P＜0.001),患者年龄为异质性来源(P＜0.05).年龄≥60岁组、术前血清ox-LDL水平高与ISR存在相关性(P＜0.05).结论 行经皮冠状动脉介入术患者术前血清ox-LDL水平高与ISR无相关性,但对于年龄≥60岁的患者术前血清ox-LDL水平高与ISR存在相关性.
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