胰岛素样生长因子-1和转化生长因子-β1在宫腔粘连患者子宫内膜表达的研究

摘要

目的：探讨胰岛素样生长因子-1（IGF-1）和转化生长因子-β1（TGF-β1）在宫腔粘连发生中的作用。方法45例宫腔粘连患者，其中轻、中、重度患者各15例，采用免疫组化法检测其正常子宫内膜组织及粘连组织中IGF-1、TGF-β1的表达水平。结果 IGF-1、TGF-β1在正常子宫内膜组织及粘连组织均有表达；在轻、中、重度粘连组患者正常子宫内膜组织中表达均低于粘连组织（P＜0．05）；随宫腔粘连程度加重，其在粘连组织中的表达逐渐增高，均呈重度组＞中度组＞轻度组（P＜0．05），且粘连组织中两者呈正相关（r＝0．53，P＜0．01）。结论随宫腔粘连加重，粘连组织中IGF-1、TGF-β1表达增高，提示其可能参与宫腔粘连的形成。%Objective To explore the effect of insulin-like growth factor-1 ( IGF-1 ) and transforming growth factor-β1 ( TGF-β1 ) on intrauterine adhesion(IUA).Methods Forty-five patients with IUA(mild 15,moderate 15,severe 15) were detected for the expression levels of IGF-1 and TGF-β1 in the normal endometrium and adhesion tissues by immunohistochemistry.Results The expressions of IGF-1 and TGF-β1 were observed in the normal endometrium and adhesion tissues,which were significantly lower in the normal endometrium than in the adhesion tissues among mild,moderate and severe adhesion groups(P<0.05).The more severe IUA was,the higher expression levels of IGF-1 and TGF-β1 in adhesion tissues were,and the highest expression levels were in the severe adhesion group while the lowest were in the mild adhesion group(P<0.05).The IGF-1 expression positively correlated with the TGF-β1 expression in the adhesion tissues (r=0.53,P<0.01).Conclusion The expressions of IGF-1 and of TGF-β1 in the adhesion tissues increase with the increasing severity of IUA,which suggests IGF-1 and TGF-β1 might involve in the development of IUA.