转化生长因子-β1及 Smad2／3在宫腔粘连患者子宫内膜组织中的表达及意义

摘要

目的：探讨转化生长因子-β1（ TGF-β1）及Smad2／3在宫腔粘连患者子宫内膜组织中的表达及意义。方法根据粘连程度将59例宫腔粘连患者分成轻度粘连组、中度粘连组、重度粘连组3组。采用免疫组化半定量法检测3组及对照组（非宫腔粘连患者）子宫内膜组织中TGF-β1、Smad2／3的蛋白表达量。结果随着宫腔粘连程度加重，患者子宫内膜组织中TGF-β1及Smad2／3的蛋白表达量均逐渐升高；中度、重度粘连组分别与对照组比较，差异均有统计学意义（ P＜0.001）。结论子宫内膜组织中TGF-β1及Smad2／3的过度表达可能参与宫腔粘连的发生发展。%Objective The expression of TGF -β1 and Smad2/3 in endometrium were investigated to explore its correlation with intrauterine adhesions ( IUA) .Methods The protein expression of TGF-β1 and Smad2/3 was examined by immunohistochemical analysis in 59 patients with IUA as study group and 21 patients as control group .The study group was subdivided into three subgroups according to the severity of adhesion , mild IUA, moderate IUA, and severe IUA sub-groups .Results There was a rising tendency of TGF -β1 and Smad2/3 protein expression from mild adhesion to sever ad-hesion.Compared with control group , the expression of TGF-β1 and Smad2/3 in the endometrium were significantly in-creased in both moderate IUA subgroup and severe IUA subgroup (P<0.001).Conclusion The overexpression of TGF -β1 and Smad2/3 in endometrium may take part in the occurrence of IUA .