Expression of Transforming Growth Factor-Beta (TGF-Beta) in Prostate Cancer Progression

摘要

We have changed from using rats to mice. This change was approved by the DOD review committee. Our hypothesis is that if we render the host immune cells insensitive to TGF-beta, these immune cells would be able to eradicate tumor cells. There are three talks. Task 1 was to establish a dominant negative TGF-beta type II receptor bearing bone marrow cells, using GFP as a selectable marker. Task 2 was to test the role of TGF-beta insensitivity in immune cell development and differentiation. Task 3 was to assess the anti-tumor activity in host animals bearing TGF-beta insensitive bone marrow cells.