为分析20株禽源多杀性巴氏杆菌的药物敏感性及质粒携带特征，采用纸片法测定细菌的药物敏感性，碱裂解法提取细菌的质粒。结果表明16株以上菌株敏感的药物有氧氟沙星、利福平、头孢唑啉、多粘菌素B、强力霉素、左氧氟沙星、氨苄青霉素、恩诺沙星和复方新诺明。13株携带有质粒，携带的质粒为1～7个。细菌耐受药物的种类与是否携带质粒无关。只有携带质粒的菌株对氟苯尼考、多粘菌素B和复方新诺明耐药。说明近期治疗禽霍乱应首选氧氟沙星、利福平、头孢唑啉、多粘菌素B、强力霉素、左氧氟沙星、氨苄青霉素、恩诺沙星和复方新诺明等药物。禽源多杀性巴氏杆菌的质粒可能与对氟苯尼考、多粘菌素B和复方新诺明的耐药有关。%This study aimed to determine the drug‐resistance and plasmid‐carrying properties of the 20 strains of Pasteurella multocida isolated from avian sources . Their sensitivity to antibiotics was determined by using the diffusion test on paper ,and the plasmids extraction by means of the alkaline lysis method .More than 80% of the isolated strains were found sensitive to Ofloxacin ,Rifampin ,Cefazolin ,Polymysin B ,Doxycycline ,Levofloxacin , Ampicillin ,Enrofloxacin and/or compound sulfamethoxazole .The plasmid‐carrying rate of the isolates was 65%with 1 to 7 plasmids found in them .There was no correlation between the drug resistance and plasmid‐carrying of the bacteria , as the strains that carried plasmids were shown only resistant to Florfenicol , Polymysin B and compound sulfamethoxazole . It suggested , however , that Ofloxacin , Rifampin , Cefazolin , Polymysin B , Doxycycline ,Levofloxacin ,Ampicillin ,Enrofloxacin and/or compound sulfamethoxazole should be preferential for treating the avian cholera .And ,the plasmids found in the P .multocida isolates might be associated with the bacterial resistance to Florfenicol ,Polymysin B and compound sulfamethoxazole .
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