Pasteurella multocida heterologous protection provided by P. multocida fur cells and outer membrane protein extracts

摘要

The invention relates to Pasteurella multocida mutants capable of conferring heterologous protection against infection caused by virulent P. multocida. These mutants are defective and fur ompH inthe ompH galE genes fur. The present invention relates to vaccine compositions against Pasteurella multocida bacterium, comprising fur ompH double mutants and galE mutants triplesfur ompH obtained from P. multocida, or outer membrane proteins extractode iron regulated (IROMPs) obtained from said mutants and a carrier and / or adyuvantesfarmacéuticamente acceptable.