HETEROLOGOUS PROTECTION AGAINST PASTEURELLA MULTOCIDA PROVIDED BY P. MULTOCIDA FUR CELLS AND THE OUTER-MEMBRANE PROTEIN EXTRACTS THEREOF

摘要

The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P . multocida. Said mutants are defective in fur ampH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P . multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.