武夷岩茶对高血糖大鼠的降糖作用

摘要

利用STZ高血糖大鼠动物模型研究武夷岩茶的降糖功效.采用腹腔注射链尿佐菌素(STZ)制备Wistar高血糖大鼠模型,根据初始空腹血糖值来进行随机分组,持续灌胃武夷岩茶30 d,试验结束前以日常空腹血糖、曲线下面积(AUC)作为平时的观测指标,取材后以空腹血清中血糖(FPG)、胰岛素(INS)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量作为观察指标.结果显示:武夷岩茶各剂量组能抑制空腹血糖的升高,相对于模型组的空腹血糖具有极显著性差异(P＜0.01),表现良好的降糖作用,而且高剂量组的降血糖效果与二甲双胍对照组在统计学上无明显差异;给武夷岩茶茶汤之后,大鼠的糖耐量得以改善(P＜0.01),且呈现良好的时效关系;武夷岩茶各剂量组均能降低糖尿病大鼠的胆固醇和甘油三酯,与模型组比较具有显著性差异(P＜0.05或P＜0.01),提高大鼠空腹血清胰岛素(P＜0.01)与胰岛素的敏感性(P＜0.05).结果表明:武夷岩茶具有显著的降糖作用.%The hypoglycemic effect of Wuyi rock tea on Wistar rats was studied.The rats were artificially induced to become diabetic by intraperitoneal injection of STZ.They were subsequently orally fed with the tea extract for 30 days.The fasting blood glucose,AUC,FPG,INS,TG,TC,LDL-C,and HDL-C of the test animals were monitored.The results showed that (a) compared with control,the treatment groups exhibited a significant inhibition on the increase of fasting blood glucose (P＜0.01);(b) no significantly different hypoglycemic effect on the rats was observed between the high-dosage tea feeding group and the metformin-administered rats;(c) the glucose tolerance of the rats fed with the tea extract was significantly improved with a sustained duration (P＜ 0.01);(d) significant reductions on TC and TG of the hyperglycemic rats were shown in the treatment groups as compared to control (P＜0.05 or P＜0.01);(e) INS of the treated rats was significantly increased (P＜0.01);(f) ISI was enhanced for the treated animals (P＜0.05).It was,thus,concluded that Wuyi rock tea had a significant hypoglycemic effect on the rats.