肿瘤相关巨噬细胞促进肿瘤血管生成和转移的研究进展

摘要

Macropahges originate from blood monocytes and can differentiate into classically activated macrophages (M1) and alternatively activated macrophages (M2) under different stimulus. As far as we know, tumor-associated macrophages (TAM) was thought to resemble M2-polarized macrophages. The tumor patients whose tumor tissues were infiltrated by lots of TAM were believed to have poor prognosis, and TAM can promote tumor angiogenesis and metastasis by diverse molecular mechanisms.Here, we review the molecular mechanisms that TAM promote tumor angiogenesis and metastasis.%巨噬细胞起源于血液单核细胞,在不同的刺激因素作用下,巨噬细胞可分化为经典激活的巨噬细胞(M1型)和选择性激活的巨噬细胞(M2型).现在认为,肿瘤相关巨噬细胞(tumor-associated macrophages,TAM)具有M2型巨噬细胞表型.TAM在肿瘤中大量浸润被认为是肿瘤患者预后不良的重要标志.TAM通过多种分子机制促进肿瘤血管生成和转移.本文就TAM促进肿瘤血管生成和转移的相关分子机制作一综述.