通过给予SD种Ⅱ级雄性大鼠4种不同蛋白质的高脂合成饲料，研究不同来源膳食蛋白质对脂质代谢的影响及其机理探讨。结果显示，大豆蛋白组和谷豆混合蛋白组血清TC、LDL-C、(VLDL-C+LDL-C)/TC明显低于酪蛋白组(P＜0.05)，而血清HDL-C、HDL-C/TC明显高于酪蛋白组(P＜0.05)。谷类蛋白组LDL-C也明显低于酪蛋白组(P＜0.05),HDL-C明显高于酪蛋白组(P＜.05)。谷类蛋白与大豆蛋白混合后，其生物利用率提高，调节血脂的作用增强。提示大豆蛋白尤其谷豆混合蛋白有预防AS形成作用。%Four groups of rats were fed semi - purified cholesterol - enriched diet containing 4 different sources of proteins (soybean protein, casein, wheat protein, wheat and soybean protein mixture) for45 days so as to study the effects of dietary animal and plant proteins on serum cholesterol metabolism. As compared with casein, soybean protein and its mixture with wheat protein induced significantly lower concentration of serum total cholesterol (TC) and LDL C, lower (VLDL - C + LDL - C) /TC ratio and higher level of HDL - C and HDL - C/TC ratio (P ＜0. 05 ). LDL - C also was significantly lower in the rats fed wheat protein than the rats fed casein, whereas HDL - C was significantly higher in rats fed wheat protein than casein (P ＜0. 05 ) . The mixture of wheat protein and soybean protein showed stronger cholesterol - lowering effect, and also improved biological value of wheat protein. The results suggested that soybean protein, especially the mixture of wheat protein and soybean protein had preventive effect on atherosclerosis.
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