二色补血草多糖铁（Ⅲ）配合物的制备及理化性质研究

摘要

Objective： To explore the best synthetic process of Limonium bicolor polysacchadde-Fe （III） complex （LPC） and its physical and chemical properties. Methods： The synthetic process conditions were optimized by response surface methodology. The stability of LPC under physiological conditions was evaluated by its hydrolysis characteristics and reducibleness. Results： The optimal synthetic conditions were water bath temperature of 73 ℃, polysaccharides-to-C6HsNa3O7 · 2H2O ratio of 5：1 and reaction pH of 8. The prepared LPC was stable under physiological pH environment. Conclusion： LPC has excellent physico- chemical properties and can be used as a new iron supplement.%目的：研究二色补血草多糖铁（Ⅲ）配合物（LPC）的最佳合成工艺及其理化性质。方法：采用响应面分析法对LPC合成条件进行优化,并根据LPC的水解及还原性实验判断其在生理条件下的稳定性。结果：LPC的最佳合成工艺为水浴温度73℃、多糖与柠檬酸三钠的质量配比5：1、反应液pH8,且理化性质稳定。结论：LPC具有较好的理化性质,有望开发成为一种新型的补铁剂。