维生素E乙酸酯制备方法与光谱表征

摘要

The synthesis of vitamin E acetate using SO4^2-/TiO2 solid super acid as a novel catalyst was investigated with respect to catalyst dose, molar ratio of acetic anhydride to vitamin E, reaction time and reaction temperature. Based on fuzzy mathematical modeling, the optimal synthesis conditions were determined to be temperature 40 ℃, reaction time 3 h, molar ratio of vitamin E to acetic anhydride 1：1.2, and catalyst dose 1.0 g. Under these conditions, the conversion rate of vitamin E was 96.6%. The product obtained was identified as vitamin E acetate by infrared spectrum （IR）, elemental analysis and ZH NMR.%利用新型催化剂固体超强酸SO4^2-／TiO2合成VE乙酸酯，研究催化剂用量、反应物配比、反应时间、反应温度等因素对合成的影响，通过模糊数学模型确定了最佳合成条件。最优合成工艺：温度40℃，时间3h，乙酸酐与VE摩尔比112，固体超强酸SO4^2-／TiO2催化剂用量1．0g，反应酯化率为96．6％。利用IR、元素分析和’HNMR对产物结构进行表征，证明得到的产物为VE乙酸酯。