茯苓多糖对Ⅱ型糖尿病小鼠降糖作用研究

摘要

Hypoglycemic effects of polysaccharides from Wolfiporia cocos (Schw.) Ryv.&Cilbn (WRP) on high-sugar, high-fat diet and STZ-induced NIDDM mice were studied. The results showed that WRP could control NIDDM mice from decreasing body weight , decrease blood glucose and plasma insulin level , Improve insulin resistance (IR)state and hyperinsulinemia. WRP exhibited the best effects at the dose of 200 mg/kg bw. Acute toxicity studies revealed no obvious symptom of toxicity of WRP.%为探讨茯苓多糖（WRP）对糖尿病的治疗作用，采用Ⅱ型糖尿病（NIDDM）小鼠模型，灌胃不同剂量的茯苓多糖28 d，然后测定小鼠血糖、血清胰岛素、胰高血糖素、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）等生化指标，并进行口服糖耐量（OGTT）试验。结果表明WRP能有效地降低血糖、血清胰岛素、胰高血糖素、TC、TG和LDL-C水平，增加HDL-C水平；能提高NIDDM小鼠葡萄糖耐受力，改善糖耐量的异常。WRP对NIDDM小鼠具有降糖作用，且能一定程度上改善糖尿病引起脂代谢紊乱情况。