ω-3多不饱和脂肪酸对2型糖尿病患者血脂及炎症因子的影响

摘要

[Objective] To investigate the effect of ω-3 polyunsaturated fatty acid (ω-3PUFA) on lipidic and the expression of C-reactive protein and interleukin-6 in type 2 diabetes mellitus.[Method] Totally 108 patients with type 2 diabetes mellitus were randomely divided into three groups including A group (ω-3PUFA-DHA +EPA),B group (ω-3PUFA-ALA),C group (control),and gave them with different types of ω-3PUFA to test the changes of lipeds,C-reactive protein and interleukin-6 on 0,3 and 6 months.[Result] After treatment with n-3PUFA,high density lipoprotein of group A was increased in 3 months (P ＜0.05) and 6 months (P ＜0.01),total cholestrol was greatly decreased after 6 months (P ＜ 0.05).The lipids between group B and group C had no difference between 3 and 6 months (P ＞ 0.05).By comparing the C-reactive protein and interleukin-6 between group A and group C,it showed that ω-3PUFA (DHA + EPA) could inhibit the expression of C-reactive protein and interleukin-6 (P ＜ 0.05).[Conclusion] n-3PUFA (DHA + EPA) could improve high density lipoprotein,lower total cholestrol,and inhibit the expression of C-reactive protein and interleukin-6.%目的:观察不同成分的ω-3PUFA对2型糖尿病患者血脂水平及C反应蛋白和白介素-6的影响.方法:采用随机双盲对照方法,将108例2型糖尿病患者随机分为3组,分别服用含有不同成分(ALA、EPA、DHA)的ω-3PUFA胶囊4g/d,观察时间为6个月,A组(金枪鱼油组,胶囊成分为ω-3PUFA-DHA+ EPA)、B组(亚麻籽油组,胶囊成分为ω-3PUFA-ALA)、C组(玉米油组,对照组).分别在基线、3个月、6个月时检测血脂、白介素-6和C反应蛋白等,进行统计学分析.结果:①组内比较:A组在3个月时HDL较治疗前升高,其差异具有统计学意义(P＜0.05),6个月时具有显著统计学差异(P＜0.01);6个月时,TC水平较治疗前降低,其差异具有统计学意义(P＜0.05);B组和C组3月、6个月时,血脂无明显变化(均P＞0.05).组间比较:3个月时,3组患者血脂水平均无显著差异(P均＞0.05);6个月时A组和C组之间HDL水平差异具有统计学意义(JP＜0.05).②组内比较:A组CRP和IL-6水平在3个月时均较治疗前降低,其差异具有统计学意义(P＜0.05),6月时具有显著统计学差异(P＜0.01);B组和C组3个月、6个月时,CRP和IL-6水平无明显变化(P均＞0.05).组间比较:3个月时,3组CRP和IL-6水平均无显著差异(P均＞0.05);6个月时A组和C组之间CRP和IL-6水平差异具有统计学意义(P＜0.05).结论:服用ω-3PUFA(金枪鱼油,胶囊成分ω-3PUFA-DHA+ EPA)4g/d可以升高2型糖尿病患者高密度脂蛋白,降低总胆固醇水平,并能降低糖尿病患者C反应蛋白和白介素-6水平.