2013年217例药品不良反应报告分析

摘要

目的：了解复旦大学附属上海市第五人民医院（以下简称“我院”）药品不良反应（ ADR）的发生情况，以促进临床合理用药。方法：回顾性调查2013年我院收集的217例ADR报告，从患者的年龄、性别、药品种类、给药途径等方面进行统计、分析。结果：217例ADR中，男女患者比例为0�7∶1�0；≥60岁患者78例（占35�94％）；静脉给药147例（占67�74％），口服给药59例（占27�19％）；抗感染药致ADR 119例，居首位；ADR临床表现主要为皮肤及其附件损害（80例，占36�87％）。结论：应加强医院ADR监测工作，合理、规范使用抗感染药，避免或减少严重的ADR发生。%OBJECTIVE:To investigate the characteristics of adverse drug reaction ( ADR ) in Shanghai Fifth People�s Hospital Affiliated to Fudan University ( hereinafter referred to as “our hospital“) so as to promote clinical rational use of drug. METHODS:217 ADR cases collected in our hospital during 2013 were analyzed statistically in terms of patients�age and gender, drug types and route of administration etc. RESULTS:The 217 ADR cases occurred in male/female ratio of 0�7∶ 1; 78 cases ( 35�94%) aged ≥60 years; 147 cases ( 67�74%) were induced via intravenous injection;59 cases(27�19%) were induced by oral drugs;the anti⁃infective drugs ranked the first in terms of ADR incidence; 80 cases ( 36�87%) manifested as lesions of skin and its appendants. CONCLUSIONS: It is important to strengthen ADR monitoring in hospital and achieve rational and standard use of anti⁃infective drugs so as to avoid or reduce the occurrence of severe ADR.