2014年南阳市第一人民医院203例药品不良反应报告分析与评价

摘要

OBJECTIVE:To evaluate the fundamental state of adverse drug reactions ( ADR) reports reported by the First People's Hospital of Nanyang ( hereinafter referred to as “our hospital”) in 2014, and to grasp the characteristics, regularity and clinical manifestations of ADR so as to provide the reference for the clinical rational use of drugs.METHODS: 203 cases of ADR reports were collected and reported in our hospital from 2014, statistical analysis was conducted on the route of administration , related drug categories and clinical manifestation , etc. RESULTS:Of the 203 ADR cases, antibiotics, injections and intravenous routes of administration were the three main factors that induced ADR .The systemic damage took the lead , accounting for 26.9%, followed by gastrointestinal system damage ( 21.1%) and skin and its accessories damage ( 11.6%) .These ADR cases were reported by 198 (97.5%) doctors,and 5 (2.5%) nurses.CONCLUSIONS: ADR monitoring must be strengthened and the related knowledge of ADR must be publicized , which can effectively guide the clinical rational use of drugs and decrease the reappearance of ADR .%目的：评价2014年南阳市第一人民医院（以下简称“我院”）药品不良反应（ adverse drug reaction ，ADR）的上报情况，掌握ADR的发生特点、规律与临床表现，为临床合理用药提供参考。方法：对我院2014年收集并上报的203例ADR报告分别从给药途径、涉及药物品种以及临床表现等方面进行统计、分析。结果：在203例ADR中，抗菌药物、注射剂及静脉给药途径是引发ADR的三大主要因素；全身性损害占26.9％，其次是胃肠系统损害（21.1％）和皮肤及其附件损害（11.6％）；ADR报告者中医师有198例（97.5％）、护士有5例（2.5％）。结论：加强ADR监测及其相关知识的宣传，可指导临床合理用药，减少ADR的重复发生。