目的：探讨不同剂型的复方盐酸氨基葡萄糖治疗骨关节炎的疗效及安全性。方法：选取2012年7月—2016年6月湖北省谷城县人民医院收治的骨关节炎患者306例作为研究对象，采用区组随机化分组方法分为胶囊组、片剂组及安慰剂组3组，每组各102例。胶囊组患者给予复方盐酸氨基葡萄糖胶囊3粒，片剂组患者给予复方盐酸氨基葡萄糖片剂3片，安慰剂组患者给予复方盐酸氨基葡萄糖胶囊1粒、片剂1粒、安慰剂1粒，1日3次。观察不同用药方案的安全性与临床疗效。结果：胶囊组、片剂组患者的关节功能与视觉模拟评分法评分均明显低于安慰剂组，差异均有统计学意义（ P＜0.05）；胶囊组与片剂组的总有效率均显著高于安慰剂组，差异均有统计学意义（ P＜0.05）；3组患者不良反应发生率的差异无统计学意义（ P＞0.05）。结论：采用复方盐酸氨基葡萄糖胶囊剂或片剂治疗骨关节炎，均疗效显著，且安全可靠。%OBJECTIVE:To probe into the efficacy and safety of different formulations of compound Glucosamine hydrochloride capsules and tablets in treatment of osteoarthritis .METHODS:306 patients with osteoarthritis admitted into Hubei Province Gucheng County People's Hospital from Jul .2012 to Jun.2016 were selected to be divided into capsule group , tablet group and placebo group via the random number table , with 102 cases in each .The capsule group were given three compound Glucosamine hydrochloride capsules , the tablet group were treated with three Glucosamine hydrochloride tablets , and the placebo group received one Glucosamine hydrochloride capsule , one Glucosamine hydrochloride tablet , three times a day .The clinical efficacy and safety of different therapeutic regimen were observed .RESULTS: The joint function recovery and visual analogue scale score of capsule group and tablet group were significantly lower than that of placebo group , with statistically significant difference ( P0.05 ) .CONCLUSIONS:The efficacy of compound Glucosamine hydrochloride capsules or tablets in treatment of osteoarthritis is remarkable with high safety .
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