细菌纤维素／肝素复合物的制备与力学性能

摘要

Heparin was immobilized within bacterial cellulose by immersing and crosslinking to produce bacterial cellulose/heparin composites. The structure and mechanical properties of the composites were also studied. FTIR results show that the char-acteristic peaks of heparin present in the structure of bacterial cellulose,SEM and XRD reveal that after immersing or crosslinking, under the effect of heparin,the microstructure of bacterial cellulose becomes more dense and has lower crystallinity and bigger crys-talline sizes,the structure and crystallinity of the composite prepared by crosslinking method have more obvious changes. Tensile property test shows that immersing and crosslinking all can improve the mechanical properties of bacterial cellulose/heparin com-posites,and the improving effect of crosslinking method is better than that of immersing method. When the concentration of heparin solution is1.5 g/100 mL,the tensile strength of crosslinked composite comes up to the maximum value 177.82 MPa,increases by 76.3% than that of the pure bacterial cellulose.%采用浸泡和交联法将肝素(Hep)固定在细菌纤维素(BC)上，研究了BC／Hep复合物的结构与力学性能。傅立叶变换红外光谱结果表明，BC结构中出现了Hep的特征吸收峰；扫描电子显微镜和X射线衍射显示，浸泡或交联后，在Hep的作用下，BC的结构变得紧密，结晶度下降，晶粒尺寸增大，其中交联法制备的复合物的结构与结晶性能变化更为明显。拉伸性能实验表明，与纯BC相比，浸泡和交联制备的BC／Hep复合物力学性能增强，交联法制备的复合物力学性能优于浸泡法，Hep溶液浓度为1.5 g／100 mL时其拉伸强度最大，可达到177.82 MPa，与纯BC相比提高了76.3%。