1例百草枯中毒患儿的药物治疗分析

摘要

Paraquat (PQ) is a kind of non-selectivity contacted herbicide of high efficiency, with the rapid effects after spraying. It deactivates soon in the soil without any delay. The toxicity of Paraquat is so strong that it can influence several organs of the body, also can cause the multi organ dysfunction syndrome (MODS) when it is serious. The lung is the major target organ called paraquat lung, with the acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) as its early manifestations, while the pulmonary fibrosis is considered to be the fatal cause in the late. stage. In this article, the author participated in the clinical treatment process for a child who was poisoned with paraquat, shared the clinical experiences, explored the difficulties of the treatments, and provided the references for the further medication.%百草枯(paraquat，PQ)是一种高效能的非选择性接触型除草剂，喷洒后起效迅速，进入土壤后迅速失活，在土壤中无残留。百草枯对人畜具有很强毒性，误服后可累及全身多个脏器，严重时可导致多器官功能不全综合征(the multi organ dysfunction syndrome，MODS)，其中肺是主要靶器官，可导致“百草枯肺”，早期表现为急性肺损伤(he acute lung injury，ALI)或急性呼吸窘迫综合征(acute respiratory distress syndrome，ARDS)，后期则出现肺泡内和肺间质纤维化，是百草枯中毒患者致死的主要原因，病死率高达50%-70%。笔者就参与临床一例百草枯中毒患儿的临床治疗过程，分享临床经验，探讨治疗难点，为百草枯中毒患儿的诊治提供参考。