纤维化淤胆性肝炎（FCH）是继发于严重的免疫功能抑制患者的一种特殊的致死性的病毒性肝炎。病理组织学特点为：汇管区纤维化、肝内显著淤胆、肝细胞气球样变和毛玻璃样变，胆管反应及轻度混合性炎症反应。其发病机制不同于普通肝炎的免疫介导的肝细胞损伤，而是因病毒在肝内大量复制并聚集而对肝细胞造成直接损伤的作用。本文就纤维淤胆性肝炎的病因、发病机制、临床病理表现和诊疗进展作一综述。%Fibrosing cholestatic hepatitis(FCH) is a lethal hepatitis secondary to serious immunosuppression. The pathology and pathogenesis of FCH is different from classic hepatitis. The lesion is characterized by peri portal fibrosis, ballooning degeneration and ground-glass of hepatocytes, prominent cholestasis and paucity of inflammation. Its pathogenesis is different from classical hepatitis associated with immune induced liver injury. Recent data suggests it is a cytopathic effect of the pre-core mutant form of HBV with over-expression of viral antigens and directly damage hepatocytes. This review summarizes the etiology, pathogenesis, clinic and pathological features, and treatment of FCH.
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