Correlation Between Aspartate Aminotransferase/Alanine Transferase Ratio (AST/ALT Ratio) and Stage of Liver Fibrosis in Patients with Chronic Hepatitis

摘要

Fibrosis is hallmark histologic event of chronic liver disease. Liver biopsy remains the gold standard for diagnosis and assessment of liver fibrosis in patients with chronic hepatitis. However, its invasive procedure and can have complication, not suitable for continous observation of liver fibrosis. The aspartate aminotransferase-alanin transferase ratio (AST/ALT ratio) has been used to evaluate prognosis of liver fibrosis and non-invasive proseduce for chronic hepatitis patients. To evaluate correlation between AST/ALT ratio and the stage of histologic liver fibrosis in chronic hepatitis patients. The study was restrospective design, where liver biopsy specimen has been collected from fourty chronic hepatitis patients during period Januari 2012 to December 2015. All histological slides were reviewed by two pathologists for evaluating histologic liver fibrosis by using Metavire score system. Patients characteristic were descriptifly analized, AST/ALT ratio and the stage of fibrosis were analized by using Spearman's correlation. The 40 patients were identified. The mean of age was 41 years, 70% patients were male. The number of patients with stage F1, F2, F3 and F4 of fibrosis respectively were 2 (5%), 16 (40%), 11 (27,5%), and 11(27,5%). The mean of AST/ALT ratio was 1,45 ± (SE mean 0,14). We found that there was statistically significant positive correlation between AST/ALT ratio with the stage of fibrosis (r = 0,843; p value< 0,01). AST/ALT ratio was correlated with the stage of fibrosis. It is recomended to used the ratio as prediction of pogressive liver functional impairment.