他汀类药物对急性心肌梗死患者经皮冠状动脉介入治疗术后再灌注心律失常的影响

摘要

目的 探讨经皮冠状动脉介入(percutanous coronary intervention,PCI)治疗术前应用他汀类药物对急性心肌梗死(acute myocardial infarction,AMI)患者再灌注心律失常的影响.方法 选择2006年2月～2008年12月首次ST段抬高型AMI发病12 h内行直接PCI治疗的患者136例,按照术前是否长期服用他汀类药物分为他汀组(40例)和非他汀组(96例).观察PCI术后2 h内两组再灌注心律失常的发生情况.结果 他汀组9例发生再灌注心律失常,发生率22.5%;非他汀组70例发生再灌注心律失常,发生率72.9%.两组再灌注心律失常发生率比较差异有统计学意义(P＜0.01).非他汀组2例因心室颤动发生心源性猝死,他汀组无一例死亡.结论 PCI术前应用他汀类药物可明显降低AMI患者再灌注心律失常的发生率,改善预后.%Objective To evaluate the effect of pretreatment with statin on reperfusion arrhythmia in patients who underwent successful primary percutanous coronary intervention(PCI) for acute myocardial infarction (AMI).Methods A total of 136 consecutive AMI patients undergoing PCI were divided into two groups according to whether receiving statin treatment before admission or not: statins group( n = 40) and non-statins group( n = 96).The reperfusion arrhythmia was observed whithin 2 h after PCI.Results The occurrence rate of reperfusion arrhythmias in statins group was significantly lower than that in non-statins group( 22.5％ vs.72.9％ ,P ＜0.01 ).2 patients died of ventricular fibrillation in non-statins group and no one died in statins group.Conclusion Pre-treatment with statin could reduce the reperfusion arrhythmias after acute myocardial infarction in patients.