Objective To compare the therapeutic effect and cardiotoxicity of chemotherapy regimen CTOP (cyclophosphamide, pirarubicin, vincristine, and prednisone) and CHOP ( cyclophosphamide, doxorubicin, vincristine,and prednisone) on non-Hodgkin lymphoma. Methods 68 patients with non-Hodgkin lymphoma were randomly divided into two groups,group A including 35 cases treated with CTOP regimen, while group B with 33 equivalent cases received CHOP regimen. The therapeutic effect and cardiotoxicity were evaluated after six courses of treatment. Results After six cycles of chemotherapy,the effective rates of two groups were similar,group A 80.0％ vs group B 72.7％( P ＞ 0.05). In cardiotoxicity respect, firstly, the number of emerging abnormal electrocardiograph in group A and group B was 3 and 10 eases respectively( P ＜0.05). Secondly, in group A, left ventricular ejection fraction(LVEF),fractional shortening(FS) and E/A of mitral valve orifice diastolic phase velocity before chemotherapy and after six cycles of chemotherapy were (62.06±4.37)％ vs (61.374±4.72)％(P＞0.05);(35.494±2.41)％ vs (34.57±2.25)％(P＜0.01);1.25±0.12 vs 1.21±0.09(P＜0.01);and in group B the data were (61.55±4.46)％0 vs (60. 274±5.28) ％( P ＜0.01);(35.30±2.10)％ vs (33.91i 1.91)％ ( P ＜0.01);1.234±0.08 vs 1.084±0. 13( P ＜0.01) correspondingly,such could be observed from ultrasonic cardiogram. Further comparatively,group A was higher than group B after six cycles of chemotherapy in E/A( P ＜0.01) ,while there were no significant differences in LVEF,FS between two groups( P ＞0.05). Last,after six cycles of chemotherapy,cardiac function became worse in group A(3 cases) and group B(8 cases) respectively,but the difference showed no statistic significance( P ＞0.05). Conclusion CTOP and CHOP regimens have similar therapeutic effect, however,cardiotoxicity of CTOP regimen is lower than that of CHOP significantly.%目的 比较环磷酰胺、吡喃阿霉素、长春新碱、泼尼松(CTOP)与环磷酰胺、多柔比星、长春新碱、泼尼松(CHOP)方案治疗非霍奇金淋巴瘤(NHL)的疗效及心脏毒性.方法 将68例NHL患者随机分成两组,治疗组35例用CTOP方案化疗,对照组33例用CHOP方案化疗,评估两组疗效及心脏毒性.结果 6个疗程后治疗组总有效率80.0%.对照组为72.7%,但差异无统计学意义(P>0.05).心脏毒性方面:①心电图(ECG)变化:6个疗程后新增ECG异常在治疗组和对照组中分别为3例、10例,两组ECG变化差异有统计学意义(P0.05),(35.49±2.41)%vs(34.57±2.25)%(P0.05),而E/A化疗后治疗组明显高于对照组,差异有统计学意义(P0.05).结论 CTOP与CHOP方案治疗NHL疗效相近,但CTOP方案心脏毒性明显低于CHOP方案.
展开▼
